Coagulopatia en enfermedad hepática severa. Intervención de factores anticoagulantes, procoagulantes y fibrinoliticos
Resumen
El Hígado es un órgano que participa en la síntesis de factores procoagulantes, anticoagulates y fibrinoliticos, de lo cual depende el balance en la coagulación. En pacientes con cirrosis hepática se pierde este balance por trastornos en el metabolismo de estos factores, así mismo, se presentan fallas en la función de síntesis hepática, disfunción del endotelio debido al estado hiperdinamico en cirrosis y significativas alteraciones tanto en el numero como en la función de las plaquetas. Por estas razones los pacientes con enfermedad hepática avanzada/cirrosis, pueden presentar episodios de sangrado por mucosa, órganos u otros tejidos o bien eventos tromboembolicos en el sistema venoso profundo de miembros inferiores, a nivel pulmonar o Trombosis de Vena Porta. Para tratar la coagulopatía de pacientes con enfermedad hepática se requiere una cuidadosa interpretación de la fisiopatología y una clara intervención terapéutica.
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DOI: http://dx.doi.org/10.61155/gen.v69i1.7
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